Ñuflo de Chaves Historical milestone · Santa Cruz de la Sierra, Comarca de Trujillo, Cáceres Image of Santa Cruz de la Sierra, not of the place itself. Conquistador born in Santa Cruz de la Sierra, who sailed for America on 2 December 1540 and founded the city of Santa Cruz de la Sierra in Alto Perú (present-day Bolivia) on 26 February 1561; he was killed on 5 October 1568. fundó Santa Cruz de la Sierra (Bolivia) en 1561 Photo: losclaudios3 (CC BY-SA 2.0) What to see and do in Santa Cruz de la Sierra