Courtyard of the Synagogue Curiosity · Alcalá de Henares, Cuenca del Henares, Madrid Image of Alcalá de Henares, not of the place itself. A courtyard opening off the Calle Mayor, opposite the Antezana hospital, which occupies the site of the main synagogue of the Alcalá Jewish quarter, the largest in what is now the Region of Madrid until the expulsion decreed in 1492. Photo: Emilio J. Rodríguez Posada (CC BY-SA 2.0) What to see and do in Alcalá de Henares